Naratriptan in the Prophylactic Treatment of Cluster Headache
نویسندگان
چکیده
Objective Naratriptan has been reported to reduce the frequency of cluster headache. The purpose of this study was to determine whether naratriptan is effective as a prophylactic treatment for cluster headache in Japan. Methods We retrospectively reviewed all 43 patients with cluster headache who received preventive treatment with naratriptan from April 2009 to April 2015. The International Classification of Headache Disorders, 3rd Edition (beta version) (ICHD-3 beta) was used to diagnose cluster headache. This study was conducted at 3 centers (Department of Neurology, Saitama Medical University; Saitama Neuropsychiatric Institute; Saitama Medical University International Medical Center). Patients were recruited from these specialized headache outpatient centers. Naratriptan was taken before the patient went to bed. Results The study population included 30 men (69.8%) and 13 women (30.2%). Twenty-two cases received other preventive treatments (51.2%), while 21 cases only received naratriptan (48.8%). Among the 43 cases, 37 patients (86.0%) achieved an improvement of cluster headache on naratriptan. Conclusion Naratriptan has been suggested as a preventive medicine for cluster headache because of the longer the biological half-life in comparison to other triptans. The internal use of naratriptan 2 hours before attacks appears to achieve a good response in patients with cluster headache.
منابع مشابه
Naratriptan May Become an Alternative Prophylactic Option for Patients with Cluster Headache
Cluster headache (CH), the most common of the trigeminal autonomic cephalalgias and one of the most painful primary headache disorders. It is characterized by attacks of severe, strictly unilateral pain that is commonly retro-orbital, lasting 15-180 minutes, and occurring from once every other day to 8 times a day (1). CH pain is associated with ipsilateral conjunctival injection, lacrimation, ...
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عنوان ژورنال:
دوره 56 شماره
صفحات -
تاریخ انتشار 2017